Já em fase senil, conhecido por ser um radical anti-Trump e que constantemente nas suas aparições em público fala do Presidente dos EUA, voltou a mostrar a sua faceta de esquerda-radical num podcast com outro anti-Trump senil Michael Moore.
O podcast centra-se essencialmente no Presidente Donald Trump, sendo este o tópico favorito de ambos talvez por serem masoquistas. Claramente já numa fase de decadência mental, De Niro crítica todos os Republicanos, dizendo e cito:
"There has not been one thing about this person that has been redeeming, as far as I can see. Nothing. For the Republicans who have fallen in line with him, I don’t understand it. It’s a disgrace. It’s beyond a disgrace. Shame on them. Shame on all of them.
Pigs have dignity. He has no dignity. He is a disgrace to the human race."
E continua com o seu rant ao Presidente (não destituído) Donald Trump:
" I’d like to see a bag of shit right in his face. Hit him right in the face like that, and let the picture go all over the world.
He needs to be humiliated. He needs to be confronted and humiliated by whoever his opponent is, his political opponent. They have to stand up to him, they don’t have to do it in an obvious physical way, but they have to have the formidability to confront him and to put him in his place because the people have to see that, to see him be humiliated."